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. 2022 Jan 4;132(1):e151685. doi: 10.1172/JCI151685

Figure 2. IL-13 lowers alters the intra- and extracellular oxidative potential by decreasing intracellular GSH and GSH:GSSG and increasing extracellular GSSG.

Figure 2

(A) IL-13 decreases intracellular GSH levels and lowers the GSH:GSSG ratio (n = 6). (B) IL-13 also decreases extracellular GSH levels but increases extracellular GSSG, lowering GSH:GSSG (n = 6). (C) IL-13 (10 ng/mL) increases expression of 15LO1, GPX4, and SLC7A11 by Western blot, with GPX4 and SLC7A11 increases quantified by densitometry (n = 4–12). Matched-pair analysis of log-transformed data was used to compare conditions.