Figure 5. Ex vivo extra- and intracellular redox balance is associated with clinical outcomes relevant to asthma.

(A) Extracellular BAL fluid GSH:GSSG ratio correlates with lung function (n = 98), as measured by predicted FEV₁% (n = 75) and associates with asthma exacerbations. (B) Intracellular GSH:GSSG correlates with predicted FEV₁% (n = 26), while in small numbers the association with baseline exacerbations (n = 15) is not significant. Pearson’s correlation testing was performed for comparisons of predicted FEV₁% with GSH:GSSG, while t tests were used for group comparisons. Data were log transformed except for predicted FEV₁%, which was normally distributed. Bars represent mean and error bars represent SEM.