Table 1.

Summary of characteristics of randomized studies.

							No. of patients		Event number: MACE
Author (yr)	Study design	Clinical setting (ACS/Mixed)	Follow-up (mo)	Nationality	Definition of composite outcome of MACE	PPI	PPI	Control	PPI	Control
Bhatt et al (2010)[17]	RCT	Mixed	3.5	Multinational, 15 countries	Composite of CV death, nonfatal MI, CABG, PCI, stroke)	O	1876	1885	55	54
Yano et al (2012)[13]	RCT	ACS	12	Japan	MI, revascularization, rehospitalization for ACS	O	65	65	8	12
Ng et al (2012)[14]	RCT	ACS	4.5	Hong Kong	CV mortality, nonfatal MI, stroke revascularization, revascularization	E	163	148	7	5
Zhang et al (2015)[15]	RCT	ACS	6	China	MI, revascularization, rehospitalization forACS	L	53	51	7	5
Wei et al (2016)[16]	RCT	ACS	6	China	cardiac death, MI, HF severe arrhythmia, angina	P	117	80	48	33
Ren et al (2011)[12]	RCT	ACS	1	China	CV mortality, nonfatal MI, strokerevascularization	O	86	86	22	22