FIG 1.

Forest plot for HR for OS associated with p53 mutation and sidedness. Multivariate analysis was performed using Cox regression models adjusting for age, sex, race, performance status, Charlson comorbidity index, chemotherapy received (left column), and further adjusting for molecular features including RAS, BRAF, and PIK3CA mutations, and MSI-high (right column). GOF, gain-of-function mutp53; HR, hazard ratio; LCC, left-sided colorectal cancer; MSI-high, microsatellite instability-high; mutp53, p53 mutation; non-GOF, non–gain-of-function mutp53; OS, overall survival; RCC, right-sided colon cancer; wtp53, wild-type p53.