Table 3.
Gene Ontology (GO) Enrichments for Proteins Associated with Platinum Response in Ovarian Serous Carcinoma
| biological processes | |||
|
| |||
| Gene Ontology ID | term | number of genes | corrected P-value |
| GO:0071294 | cellular response to zinc ion | 4 | 9.61 × 10−05 |
| GO:0075733 | intracellular transport of virus | 4 | 1.28 × 10−03 |
| GO:0046794 | transport of virus | 4 | 1.28 × 10−03 |
| GO:1902579 | multiorganism localization | 4 | 1.28 × 10−03 |
| GO:0044766 | multiorganism transport | 4 | 1.28 × 10−03 |
| GO:0010043 | response to zinc ion | 4 | 1.53 × 10−03 |
| GO:0015980 | energy derivation by oxidation of organic compounds | 7 | 1.83 × 10−03 |
| GO:0016032 | viral process | 9 | 2.92 × 10−03 |
| GO:0044764 | multiorganism cellular process | 9 | 2.92 × 10−03 |
| GO:0006091 | generation of precursor metabolites and energy | 7 | 3.08 × 10−03 |
| GO:0022900 | electron transport chain | 5 | 3.08 × 10−03 |
| GO:0022904 | respiratory electron transport chain | 5 | 3.08 × 10−03 |
| GO:1902396 | protein localization to tight junction | 2 | 3.23 × 10−03 |
| GO:0044419 | interspecies interaction between organisms | 9 | 3.90 × 10−03 |
| GO:0044403 | symbiosis, encompassing mutualism through parasitism | 9 | 3.90 × 10−03 |
| GO:0042773 | ATP synthesis coupled electron transport | 4 | 3.90 × 10−03 |
| GO:0042775 | mitochondrial ATP synthesis coupled electron transport | 4 | 3.90 × 10−03 |
| GO:0006119 | oxidative phosphorylation | 4 | 6.26 × 10−03 |
| GO:0045333 | cellular respiration | 5 | 6.26 × 10−03 |
| GO:0000056 | ribosomal small subunit export from nucleus | 2 | 6.45 × 10−03 |
| GO:0051649 | establishment of localization in cell | 12 | 7.57 × 10−03 |
| GO:0002576 | platelet degranulation | 4 | 9.69 × 10−03 |
| GO:0000055 | ribosomal large subunit export from nucleus | 2 | 9.69 × 10−03 |
| GO:0051764 | actin cross-link formation | 2 | 9.69 × 10−03 |
| GO:0036018 | cellular response to erythropoietin | 2 | 9.69 × 10−03 |
| GO:0055114 | oxidation—reduction process | 9 | 9.69 × 10−03 |
| GO:0034333 | adherens junction assembly | 3 | 9.69 × 10−03 |
| GO:0007010 | cytoskeleton organization | 8 | 1.19 × 10−02 |
| GO:0071248 | cellular response to metal ion | 4 | 1.64 × 10−02 |
| GO:0000054 | ribosomal subunit export from nucleus | 2 | 1.87 × 10−02 |
| GO:0071426 | ribonucleoprotein complex export from nucleus | 2 | 1.87 × 10−02 |
| GO:0046034 | ATP metabolic process | 4 | 1.98 × 10−02 |
| GO:0071241 | cellular response to inorganic substance | 4 | 2.21 × 10−02 |
| GO:0019058 | viral life cycle | 5 | 2.48 × 10−02 |
| GO:0051641 | cellular localization | 12 | 2.55 × 10−02 |
| GO:0009205 | purine ribonucleoside triphosphate metabolic process | 4 | 2.72 × 10−02 |
| GO:0043297 | apical junction assembly | 3 | 2.72 × 10−02 |
| GO:1902414 | protein localization to cell junction | 2 | 2.86 × 10−02 |
| GO:0071166 | ribonucleoprotein complex localization | 2 | 2.86 × 10−02 |
| GO:0006120 | mitochondrial electron transport, NADH to ubiquinone | 3 | 2.89 × 10−02 |
| GO:0009199 | ribonucleoside triphosphate metabolic process | 4 | 2.93 × 10−02 |
| GO:0009144 | purine nucleoside triphosphate metabolic process | 4 | 2.95 × 10−02 |
| GO:0044765 | single-organism transport | 13 | 3.96 × 10−02 |
| GO:0009141 | nucleoside triphosphate metabolic process | 4 | 3.99 × 10−02 |
| GO:0009167 | purine ribonucleoside monophosphate metabolic process | 4 | 3.99 × 10−02 |
| molecular functions | |||
|
| |||
| Gene Ontology ID | term | number of genes | corrected P-value |
| GO:0008536 | Ran GTPase binding | 3 | 4.02 × 10−02 |
| cellular components | |||
|
| |||
| Gene Ontology ID | term | number of genes | corrected P-value |
| GO:0031967 | organelle envelope | 13 | 5.31 × 10−06 |
| GO:0031975 | envelope | 13 | 5.31 × 10−06 |
| GO:0005635 | nuclear envelope | 8 | 7.72 × 10−05 |
| GO:0070062 | extracellular exosome | 18 | 7.72 × 10−05 |
| GO:0043230 | extracellular organelle | 18 | 7.72 × 10−05 |
| GO:0065010 | extracellular membrane-bounded organelle | 18 | 7.72 × 10−05 |
| GO:0031143 | pseudopodium | 3 | 4.20 × 10−04 |
| GO:0031988 | membrane-bounded vesicle | 18 | 6.78 × 10−04 |
| GO:0005643 | nuclear pore | 4 | 6.78 × 10−04 |
| GO:0044421 | extracellular region part | 18 | 1.12 × 10−03 |
| GO:0005746 | mitochondrial respiratory chain | 4 | 1.12 × 10−03 |
| GO:0046930 | pore complex | 4 | 1.29 × 10−03 |
| GO:0005829 | cytosol | 16 | 1.58 × 10−03 |
| GO:0070469 | respiratory chain | 4 | 1.58 × 10−03 |
| GO:1990204 | oxidoreductase complex | 4 | 1.58 × 10−03 |
| GO:0031982 | vesicle | 17 | 2.48 × 10−03 |
| GO:0043227 | membrane-bounded organelle | 30 | 2.91 × 10−03 |
| GO:0030018 | Z disc | 4 | 2.91 × 10−03 |
| GO:0031674 | I band | 4 | 4.46 × 10−03 |
| GO:0005747 | mitochondrial respiratory chain complex I | 3 | 5.48 × 10−03 |
| GO:0031093 | platelet alpha granule lumen | 3 | 6.68 × 10−03 |
| GO:0005576 | extracellular region | 18 | 6.68 × 10−03 |
| GO:0032991 | macromolecular complex | 17 | 8.98 × 10−03 |
| GO:0012505 | endomembrane system | 15 | 1.05 × 10−02 |
| GO:0044430 | cytoskeletal part | 9 | 1.05 × 10−02 |
| GO:0044455 | mitochondrial membrane part | 4 | 1.07 × 10−02 |
| GO:0034774 | secretory granule lumen | 3 | 1.09 × 10−02 |
| GO:0030017 | sarcomere | 4 | 1.10 × 10−02 |
| GO:0031091 | platelet alpha granule | 3 | 1.13 × 10−02 |
| GO:0005916 | fascia adherens | 2 | 1.24 × 10−02 |
| GO:0044449 | contractile fiber part | 4 | 1.33 × 10−02 |
| GO:0030863 | cortical cytoskeleton | 3 | 1.49 × 10−02 |
| GO:0030016 | myofibril | 4 | 1.49 × 10−02 |
| GO:0043292 | contractile fiber | 4 | 1.71 × 10−02 |
| GO:0043234 | protein complex | 15 | 1.72 × 10−02 |
| GO:0060205 | cytoplasmic membrane-bounded vesicle lumen | 3 | 1.72 × 10−02 |
| GO:0031983 | vesicle lumen | 3 | 1.73 × 10−02 |
| GO:0070069 | cytochrome complex | 2 | 1.73 × 10−02 |
| GO:0005856 | cytoskeleton | 10 | 2.00 × 10−02 |
| GO:0043034 | costamere | 2 | 2.07 × 10−02 |
| GO:0048471 | perinuclear region of cytoplasm | 6 | 2.16 × 10−02 |
| GO:0044448 | cell cortex part | 3 | 2.89 × 10−02 |
| GO:0005743 | mitochondrial inner membrane | 5 | 3.68 × 10−02 |
| GO:0031965 | nuclear membrane | 4 | 3.74 × 10−02 |