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Correlation of SPP1 with immune infiltration level in HNSCC. (a) SPP1 expression is significantly negatively related to tumor purity and has significant positive correlations with infiltrating levels of CD4+ T cells, macrophages, and dendritic cells. Evaluation of the relationship between SPP1 and immune infiltration by the (b) Est_immune score, (c) ESTIMATE score, and (d) stromal score.
