FIG. 3.

Inhibition of syncytia formation by anti-CD4 antibody and antiretroviral drugs. MT-2 cells infected with HIV-1 demonstrated 74% HIV-1 syncytia in this experiment. Prior to infection, CD4 receptors on MT-2 cells were blocked with anti-CD4 antibodies or nonspecific antibodies of the same isotype (anti-CD4 and Isotype, respectively). HIV-1-infected MT-2 cells were also cultured in the presence or absence of the antiviral compounds ddC (20 μM) or ZDV (0.5 μM).