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. 2021 Dec 17;8:748486. doi: 10.3389/fcvm.2021.748486

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Copyright © 2021 Pan, Liao, Dai, Li, Yan, Mai, Liu, Liao, Qiu and Zhou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inhibition of S1PR2 by JTE013 reduced inflammatory infiltration and angiogenesis. (A,E) Lesion CD4+ T-cell numbers and corresponding analysis. (B,F) Lesion CD8+ T-cell numbers and corresponding analysis. (C,G) Lesion MPO+ neutrophil numbers and corresponding analysis. (D,H) Lesion CD31+ micro-vessel numbers and corresponding analysis. (I) RT-qPCR determined lesion mRNA levels of IL-1β, IL-6, MCP-1, TNF-α, E-selectin, ICAM-1, VCAM-1, CXCL-2, and CXCL-5. (J,K) Analysis of MMP2 and MMP9 mRNA expression. n = 6 mice per group. ***p < 0.001 vs. the vehicle group. Scale: 200 μm, inset: 50 μm. Data are expressed as means ± SD. Myeloperoxidase (MPO), a marker for neutrophil abundance.