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. 2021 Dec 17;8:748486. doi: 10.3389/fcvm.2021.748486

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Copyright © 2021 Pan, Liao, Dai, Li, Yan, Mai, Liu, Liao, Qiu and Zhou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inhibition of S1PR2 by JTE013 diminished macrophages accumulation and the hallmarks of M1 macrophage. (A,B) Lesion Mac-3+ area and corresponding analysis (n = 6). (C–F) Representative immunoblot and the corresponding analysis of mouse iNOS, MCP1, and TNFα in each group (n = 6). (G–I) Representative immunoblot and the corresponding analysis of mouse Arg1 and CD206 (n = 6). Scale: 200 μm, inset: 50 μm. Data are expressed as means ± SD.