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. 2021 Dec 17;8:748486. doi: 10.3389/fcvm.2021.748486

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Copyright © 2021 Pan, Liao, Dai, Li, Yan, Mai, Liu, Liao, Qiu and Zhou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inhibition of S1PR2 by JTE013 reduced NETs accumulation. (A) Representative images of CitH3+ (green) MPO+ (red) double-immunofluorescence staining NETs area in mouse TAD lesions from each group. (B) The JTE013 treatment diminished NETs density (n = 4). (C–E) Representative immunoblot and the corresponding analysis of mouse CitH3 and SPHK1 in each group (n = 6). (F,G) JTE013 treatment reduced serum CitH3 and S1P levels (n = 6). Scale: 50 μm. Data are expressed as means ± SD. CitH3, a specific marker of NETs; MPO, a marker for neutrophil abundance.