Figure 2.

Bone and joint vasculature and perivascular niches. Confocal images showing blood vessels and perivascular cells in bones and joints. Exemplar bones and joint sections immuno-stained for endothelial and perivascular cell markers as indicated on the images (A–C). The changes and vascular cells and perivascular microenvironments can be observed during stress conditions such as radiation-induced injury. Specifically, the tile view imaged demonstrate the changes in vascular morphology and accumulation of adipocytes post radiation (B, C). Scale bar represents 200 μm. gp, growth plate; ep, epiphysis.