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. 2021 Dec 17;12:798211. doi: 10.3389/fimmu.2021.798211

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Copyright © 2021 Kumar, Saraber, Ding and Kusumbe

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Vascular ageing across different tissues: Vascular ageing causes the decrease in endothelial heterogeneity of the bone but not the overall vessel density. This age-dependent change of the bone marrow vasculature is hallmarked by the decrease of type-H vessels (Left). Across all organs, different vascular changes are observed during the ageing process. Decreased vessel density, artery numbers and pericytes number are observed in spleen, kidney, thymus and liver. Fewer changes are observed in heart, brain, and lung (middle). On the other hand, gut, skin, and uterus maintain their vasculature integrity during ageing (right).