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. 2021 Dec 17;12:797919. doi: 10.3389/fimmu.2021.797919

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Copyright © 2021 Tsang, Chua, To, Wong, Tu, Kwok, Wong, Wang, Zhang, Rosa Duque, Chan, Chu, Pang, Tam, Lau, Wong, Leung, Yuen, Kwan and Ip

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SARS-CoV-2-specific RBD and T cell responses over time. (A) Regression analysis of the measured RBD IgG ratio in convalescent serum was plotted against the days after diagnosis. The best fitting trendline is shown. The calculated t_1/2 was 121.6 days and the estimated duration of antibodies was 7.9 months compared with the average basal level obtained from uninfected individuals. (B) Representative T cell subset frequencies in PBMC of recovered patients were plotted against the post-infection period showing a flat slope for (i) CD4+ and (ii) CD8+, indicating a sustained T cell response to SARS-CoV-2 virus in recovered pediatric patients.