Table 2.
Induction by SP or acute hypobaric hypoxia of negative correlations of OGDHC or tryptophan with amino acids in the cerebella of NP or P rats.
| ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Non-pregnant rats (NP) | Pregnant rats (P) | |||||||||||
| ∑ OGDHC | ∑ TRP | ∑ OGDHC | ∑ TRP | |||||||||
| Control | SP | Hypoxia | Control | SP | Hypoxia | Control | SP | Hypoxia | Control | SP | Hypoxia | |
| TRP or OGDHC | 0.71 | 0.46 | 0.53 | 0.71 | 0.46 | 0.53 | 0.85 | −0.32 | 0.05 | 0.85 | −0.32 | 0.05 |
| ALA | 0.12 | −0.58 | −0.94 | 0.39 | 0.15 | −0.68 | −0.35 | −0.34 | −0.17 | −0.21 | −0.58 | −0.02 |
| ARG | −0.3 | −0.45 | −0.94 | −0.14 | 0.25 | −0.66 | −0.33 | −0.25 | −0.03 | −0.45 | −0.77 | −0.52 |
| ASP | −0.47 | −0.66 | −0.9 | −0.4 | –0.44 | −0.33 | −0.04 | −0.67 | −0.06 | 0.01 | −0.04 | 0.58 |
| GABA | −0.4 | −0.61 | −0.95 | −0.3 | −0.32 | −0.56 | −0.55 | −0.21 | −0.12 | −0.55 | −0.73 | −0.45 |
| GLU | 0.06 | −0.72 | −0.84 | 0.3 | −0.36 | −0.39 | 0.33 | –0.58 | −0.22 | 0.64 | 0.52 | 0.89 |
| GLY | −0.4 | −0.35 | −0.95 | −0.41 | 0.39 | −0.56 | −0.51 | −0.23 | −0.15 | −0.59 | −0.78 | −0.49 |
| HIS | −0.11 | −0.39 | −0.94 | −0.05 | 0.40 | −0.58 | 0.76 | −0.32 | 0.03 | 0.53 | −0.43 | 0.3 |
| ILE | −0.35 | −0.58 | −0.95 | −0.1 | 0.04 | −0.56 | −0.44 | −0.21 | 0.14 | −0.46 | −0.8 | −0.39 |
| LEU | −0.31 | −0.64 | −0.95 | −0.17 | −0.04 | −0.6 | −0.42 | −0.24 | 0.19 | −0.48 | −0.78 | −0.27 |
| LYS | 0.28 | −0.29 | −0.69 | 0.62 | 0.39 | −0.67 | 0.07 | 0.27 | 0.24 | −0.08 | −0.84 | 0.33 |
| MET | 0 | 0 | −0.65 | −0.05 | 0.77 | −0.43 | −0.15 | 0.24 | 0.63 | −0.63 | −0.91 | −0.31 |
| PHE | −0.24 | −0.17 | −0.95 | −0.25 | 0.06 | −0.6 | −0.04 | −0.11 | 0.08 | −0.43 | −0.81 | −0.64 |
| SER | 0.03 | −0.5 | −0.19 | 0.01 | −0.34 | −0.11 | 0.36 | 0.42 | 0.44 | 0.02 | −0.66 | 0.12 |
| TYR | 0.32 | −0.45 | −0.89 | 0.47 | 0.69 | −0.63 | −0.08 | −0.32 | 0.13 | −0.26 | −0.57 | 0.09 |
| VAL | −0.18 | 0.35 | 0.11 | −0.11 | 0.024 | 0.69 | 0.76 | 0.48 | 0.36 | 0.79 | 0.22 | −0.79 |
| Sum | –1.24 | –5.58 | –11.09 | 0.52 | 2.12 | –6.14 | 0.22 | –2.39 | 1.54 | –1.3 | –8.28 | –1.52 |
| p vs. control | 0.008 0.0008 | 0.005 | 0.0004 | |||||||||
| p SP vs. hypoxia | 0.002 | 0.01 | 0.001 | 0.006 | ||||||||
| p P vs. NP | 0.007 0.0006 | 0.006 0.003 | ||||||||||
∑ OGDHC—the algebraic sum of correlation coefficients of the OGDHC activity and each of the amino acids.
∑ TRP—the algebraic sum of correlation coefficients of tryptophan and each of the other amino acids or OGDHC activity.
NP rats: control n = 17, SP n = 13, hypoxia n = 8. P rats: control n = 8, SP n = 11, hypoxia n = 10.
The three bottom lines show p values of the statistically significant (p < 0.05) differences between the indicated groups, estimated by the Wilcoxon signed rank test.
The strength of the negative correlations is estimated by the algebraic sum of correlation coefficients of OGDHC or tryptophan with other components. The algebraic sums for the hypoxic rats have been calculated using the published data (9). The parameters exhibiting statistically significant differences and the corresponding p-values are marked in bold. The p-values at the level of a trend are shown in italic.