TABLE 2.
Univariate Cox regression analysis and Multivariate Cox regression analysis adjusted for age.
| Univariate cox regression analysis | |||||
|---|---|---|---|---|---|
| HR | St. Err | p | 95% conf. Interval | ||
| Relative decline of FVC⩾10% (within a 24-month period) (IN-def.) | 0.86 | 0.16 | 0.43 | 0.59 | 1.24 |
| Relative decline of FVC ⩾5-<10% and worsening of symptoms (within a 24-month period) (IN-def.) | 1.03 | 0.19 | 0.84 | 0.72 | 1.49 |
| Absolute decline of FVC⩾10% (within a 24-month period) (CO-def.) | 1.01 | 0.19 | 0.93 | 0.69 | 1.48 |
| Relative decline of FVC ⩾5-<10% and worsening at HRCT (within a 24-month period) (IN-def.) | 1.03 | 0.19 | 0.85 | 0.71 | 1.50 |
| Absolute decline of FVC⩾5% (within the previous 6 months) (UILD-def.) | 1.13 | 0.25 | 0.56 | 0.73 | 1.75 |
| Worsening of symptoms (within the previous 6 months) (UILD-def.) | 2.13 | 0.43 | <0.0001 | 1.43 | 1.17 |
| Annualized absolute decline of FVC⩾5% (within 6–24 months) (RE-def.) | 1.04 | 0.23 | 0.84 | 0.59 | 1.60 |
| Absolute decline of DLCO⩾15% (within a 24-month period) (CO-def.) | 1.01 | 0.24 | 0.08 | 0.64 | 1.61 |
| Worsening of respiratory symptoms and an increased extent of fibrosis (IN-def.) | 2.78 | 0.66 | <0.0001 | 1.73 | 4.45 |
| Absolute decline of FVC ⩾5-<10% (within a 24-month period) and worsening at HRCT (CO-def.) | 1.51 | 0.50 | 0.21 | 0.79 | 2.82 |
| Absolute decline of FVC ⩾5-<10% (within a 24-month period) and Worsening of symptoms (CO-def.) | 2.34 | 0.71 | 0.005 | 1.28 | 4.24 |
| Multivariate Cox regression analysis adjusted for age | |||||
| HR | St. Err | p | 95% conf. Interval | ||
| Relative decline of FVC⩾10% (within a 24-month period) (IN-def.) | 0.38 | 0.21 | 0.08 | 0.12 | 1.15 |
| Relative decline of FVC ⩾5-<10% and worsening of symptoms (within a 24-month period) (IN-def.) | 0.23 | 0.19 | 0.07 | 0.47 | 1.16 |
| Absolute decline of FVC⩾10% (within a 24-month period) (CO-def.) | 2.11 | 1.21 | 0.19 | 0.68 | 6.51 |
| Relative decline of FVC ⩾5-<10% and worsening at HRCT (within a 24-month period) (IN-def.) | 1.67 | 1.09 | 0.42 | 0.46 | 6.01 |
| Absolute decline of FVC⩾5% (within the previous 6 months) (UILD-def.) | 1.41 | 0.53 | 0.35 | 0.67 | 2.95 |
| Worsening of symptoms (within the previous 6 months) (UILD-def.) | 4.45 | 3.09 | 0.03 | 1.14 | 17.34 |
| Annualized absolute decline of FVC⩾5% (within 6–24 months) (RE-def.) | 0.88 | 0.33 | 0.74 | 0.42 | 1.84 |
| Absolute decline of DLCO⩾15% (within a 24-month period) (CO-def.) | 1.27 | 0.47 | 0.52 | 0.60 | 2.65 |
| Worsening of respiratory symptoms and an increased extent of fibrosis (IN-def.) | 1.17 | 0.67 | 0.77 | 0.38 | 3.64 |
| Absolute decline of FVC ⩾5-<10% (within a 24-month period) and worsening at HRCT (CO-def.) | 1.14 | 1.11 | 0.88 | 0.17 | 7.69 |
| Absolute decline of FVC ⩾5-<10% (within a 24-month period) and Worsening of symptoms (CO-def.) | 1.07 | 0.89 | 0.93 | 0.21 | 5.49 |