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. 2021 Dec 17;15:784154. doi: 10.3389/fncel.2021.784154

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Copyright © 2021 Liu, Wu, Tang, Li, Liu, Wang and Ke.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The hematoma volume of the three groups. (A) The brain hematoma were successfully induced 3 day after collagenase IV injection in ICH and CLB + ICH group. (B) There was no significant difference in hematoma volume between the ICH and CLB + ICH group 3 days after ICH induction (p > 0.05). *P < 0.05, compare to SO group. SO group, n = 5; ICH group, n = 5; and CLB + ICH group, n = 5.