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. 2021 Dec 17;15:784154. doi: 10.3389/fncel.2021.784154

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Copyright © 2021 Liu, Wu, Tang, Li, Liu, Wang and Ke.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Brain water content of the three groups. There was a significant increase in the brain water content of ipsilateral cortex of the ICH group and CLB + ICH group compared to that in the sham group (*P < 0.05). Seven days after ICH, CLB significantly inhibited regression of ICH-induced cerebral edema (△, P < 0.05). There was a significant decrease in the brain water content for rats in the ICH group (#, P < 0.05), but there was no significant difference in the CLB + ICH group (P > 0.05). SO group, n = 5. ICH group, n = 5; and CLB + ICH group, n = 5, 3 or 7 days after ICH.