Table 6.
Clinical characteristics and metabolic profile of ABCA1 rs2230806 genotypes in overweight/obese and non-obese control subjects.
| Overweight/Obese control | Non-obese control | |||||
|---|---|---|---|---|---|---|
| GG (233) | GA (421) | AA (151) | GG (94) | GA (152) | AA (46) | |
| Clinical characteristics | ||||||
| Age (years) | 35.83 ± 3.71 | 36.17 ± 5.19 | 35.62 ± 3.40 | 34.93 ± 4.06 | 35.34 ± 3.81 | 35.04 ± 3.64 |
| Gestation age (weeks) | 39.21 ± 0.99 | 39.27 ± 0.95 | 39.24 ± 0.84 | 39.04 ± 1.21 | 39.18 ± 0.88 | 39.19 ± 0.94 |
| Prepregnancy BMI (kg/m2) | 21.98 ± 2.15 | 22.11 ± 2.54 | 21.90 ± 3.18 | 18.70 ± 1.37 | 18.82 ± 1.34 | 19.03 ± 1.17 |
| Weight gain during pregnancy (kg) | 14.45 ± 3.99 | 14.43 ± 4.86 | 14.73 ± 3.95 | 12.32 ± 3.14 | 12.39 ± 2.97 | 11.81 ± 3.10 |
| Delivery BMI (kg/m2) | 27.65 ± 1.91 | 27.80 ± 2.09 | 27.95 ± 2.58 | 23.46 ± 1.16 | 23.57 ± 1.08 | 23.53 ± 0.95 |
| Neonatal birth height (cm) | 49.97 ± 1.87 | 49.90 ± 1.95 | 50.02 ± 2.18 | 49.54 ± 1.84 | 49.48 ± 1.62 | 49.53 ± 2.39 |
| Neonatal birth Weight (g) | 3397.63 ± 369.76 | 3409.30 ± 373.40 | 3407.53 ± 409.17 | 3278.28 ± 430.57 | 3272.76 ± 346.10 | 3249.58 ± 328.66 |
| SBP (mmHg) | 116.59 ± 9.90 | 115.72 ± 10.41 | 116.08 ± 9.97 | 114.26 ± 9.66 | 113.25 ± 9.17 | 111.39 ± 10.85 |
| DBP (mmHg) | 72.06 ± 7.57 | 72.93 ± 7.85 | 72.13 ± 7.32 | 71.63 ± 7.99 | 71.76 ± 7.36 | 70.00 ± 7.73 |
| Metabolic profile | ||||||
| Fasting Ins (μU/ml) | 11.03 ± 4.99 | 10.56 ± 4.31 | 11.14 ± 4.99 | 8.71 ± 3.67 | 8.82 ± 4.46 | 9.14 ± 3.64 |
| Fasting Glu (mmol/L) | 4.39 ± 0.35 | 4.39 ± 0.38 | 4.42 ± 0.35 | 4.34 ± 0.32 | 4.33 ± 0.36 | 4.47 ± 0.32 |
| HOMA-IR | 2.15 ± 0.97 | 2.07 ± 0.88 | 2.21 ± 1.01 | 1.67 ± 0.69 | 1.70 ± 0.90 | 1.80 ± 0.70 |
| Triglycerides (mmol/L) | 3.64 ± 1.30 | 3.83 ± 1.64 | 3.65 ± 1.40 | 3.46 ± 1.08 | 3.47 ± 1.33 | 3.38 ± 1.31 |
| TC (mmol/L) | 6.14 ± 1.11 | 6.04 ± 1.06 | 5.85 ± 1.10* a | 6.26 ± 1.03 | 6.31 ± 1.07 | 6.23 ± 1.12 |
| HDL-C (mmol/L) | 2.00 ± 0.37 | 1.96 ± 0.40 | 1.95 ± 0.44 | 2.11 ± 0.39 | 2.10 ± 0.44 | 2.03 ± 0.47 |
| LDL-C (mmol/L) | 3.31 ± 1.19 | 3.12 ± 0.93* a | 3.01 ± 0.87* a | 3.32 ± 0.91 | 3.36 ± 0.95 | 3.40 ± 0.96 |
| Atherogenic index | 2.13 ± 0.56 | 2.14 ± 0.55 | 2.09 ± 0.65 | 2.03 ± 0.65 | 2.09 ± 0.63 | 2.14 ± 0.51 |
| apoA1 (g/L) | 2.39 ± 0.48 | 2.37 ± 0.41 | 2.34 ± 0.43 | 2.40 ± 0.42 | 2.38 ± 0.45 | 2.29 ± 0.32 |
| apoB (g/L) | 1.17 ± 0.27 | 1.14 ± 0.25 | 1.11 ± 0.28* a | 1.18 ± 0.27 | 1.19 ± 0.27 | 1.20 ± 0.25 |
a
compared with GG genetype carriers in the same group *p < 0.05.