Table 2.

Number of studying reporting structural and functional brain MRI changes in relation to myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).

Findings	Number of studies
	Structural					Functional
	Myelination	White matter volume	Gray matter volume	Total intracranial volume	Circulation	Functional connectivity
No regional or global group mean differences	3	3	2	0	2	*
Abnormal correlation with physiological measures	4	2	1	0	1	0
Correlation with symptom severity	1	0	1	1	0	3
Group mean differences	0	0	0	1	0	3
Regional group mean differences	2	2	1	0	1	*
Correlation with disease duration	0	2	0	0	0	0
Evidence of cortical compensation	3	0	0	0	0	0

^*Indicating this brain MRI change has not been studied/reported.