Table 1.
Patient demographics of the sevoflurane and the midazolam group.
| Sevoflurane group | Midazolam group | p-value | |
|---|---|---|---|
| N | 20 | 17 | |
| Male | 55% (11) | 59% (10) | 0.821 |
| Gestational age (wk) | 38+1 (36+5 – 38+5) | 37+6 (34+5 – 38+1) | 0.111 |
| Birth weight (kg) | 3.0 (2.7–3.3) | 2.8 (1.9–3.1) | 0.070 |
| Apgar 5 min | 8 (8,9) | 8 (7-8) | 0.478 |
| o/e LHR | 50 (41–58) | 40 (33-54) | 0.337 |
| Preoperative mechanical ventilation (%) | 85% (17) | 100% | 0.101 |
| Preoperative VA-ECMO | 0% | 29% (5) | 0.022 |
| Intraoperative VA-ECMO | 0% | 0% | 1.00 |
| Left sided defect (%) | 85% (17) | 65% (11) | 0.977 |
| Liver-up | 25% (5) | 71% (12) | 0.005 |
| Age at surgery (d) | 3 (2–4) | 6 (3-12) | 0.008 |
| Thoracoscopy/laparotomy | 40/60% (8/12) | 23/77% (4/13) | 0.026 |
| Conversion | 100% (8) | 0% | 0.002 |
| Duration of surgery (min) | 95 (70–125) | 182 (114–203) | 0.000 |
| Defect size (n) | 6A, 8B, 5C, 1D | 1A, 9B, 6C,1D | 0.185 |
| Patch (%) | 60% (12) | 88% (15) | 0.056 |
| VIS-score preoperative | 0 (0–5)$ | 17 (10–25)$ | 0.000 |
| VIS-score intraoperative | 9 (5-25)$ | 17 (12–35)$ | 0.010 |
| VIS-score postoperative (ug/kg) | 2 (0–11)$ | 17 (10–28)$ | 0.001 |
| Rocuronium bolus dosage intraoperative (mg/kg) | 0.8 (0.6–1.0) | - | |
| Vecoronium bolus dosage during induction (mg/kg) | - | 0.2 (0.15–0.21) | |
| Vecoronium perfusor dosage intraoperative (mg/kg/h) | - | 0.09 (0.05–0.10) | |
| Fentanyl bolus dosages during induction (ug/kg) | 2.3 (1.7–2.9) | 5 (4–7) | 0.000 |
| Cumulative fentanyl bolus dosages intraoperative (ug/kg/h) | 6.2 (4.1–11.5) | 10 (7–28) | 0.119 |
| Fentanyl perfusor dosages intraoperative (ug/kg/h) | - | 4 (3–5) | |
| Sevoflurane concentration [end expired concentration (%)] | 1.5 (1.1–1.9)* | - | - |
| Midazolam perfusor dosage preoperative (ug/kg/h) | 47 (0–92) | 40 (30–50) | 0.735 |
| Midazolam perfusor dosage intraoperative (ug/kg/h) | 47 (0–67) | 100 (68–100) | 0.003 |
| Midazolam perfusor dosage postoperative (ug/kg/h) | 39 (26–99) | 50 (20–50) | 0.647 |
| Midazolam bolus intraoperative (%) | 5% (1) | 59% (10) | 0.000 |
$
Data presented as median (IQR) or (range).
*
Range of the mean values.