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. 2021 Dec 17;9:711149. doi: 10.3389/fcell.2021.711149

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Copyright © 2021 Xie, Guo, Zhong, Wang, Liang, Zeng, Liu, Chen, Tang, Wu, Zhang, Ma, Wang, Ou, Gu, Chen, Qiu and Duan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ITGB1 inhibition attenuated the aggressiveness of HCC cells. (A) Wound-healing assays were performed to measure cell migration of HCC1, 2, and 3 cells transfected with ITGB1 siRNA for 24 h. Scale bar = 100 µm. (B) The effects of ITGB1 siRNA on cell viability of sorafenib-treated HCC1, 2, and 3 cells were measured after 48 h. Values are presented in mean ± SD. *p < 0.05, ***p < 0.001, ****p < 0.0001.