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. 2021 Dec 17;9:802457. doi: 10.3389/fcell.2021.802457

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Copyright © 2021 Xu, Liao, Li, Zhou, Li, Zhang, Hu, Yang and Hou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The development of human peripheral RPE and macular RPE (A-B). Trajectory analysis of the transition of the hRPE along pseudotime. The shades of color represent the order of the time (A). macular RPE (B). peripheral RPE (C). Trajectory analysis of macular RPE subpopulations over pseudotime. Cell types are distinguished by different colors (D). Pseudotime changes in important transcription factors and receptors associated with macular RPE (E). Trajectory analysis for peripheral RPE subpopulations along pseudotime. Cell types are distinguished by different colors (F). Pseudotime changes in important transcription factors and receptors associated with peripheral RPE.