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. 2021 Dec 17;9:787581. doi: 10.3389/fcell.2021.787581

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Copyright © 2021 Shafaattalab, Li, Gunawan, Kim, Jayousi, Maaref, Song, Weiss, Solaro, Qu and Tibbits.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Influence of stimulation frequency on action potential duration in WT (black) and I79N^+/− (blue) TNNT2 hiPSC-CMs. (A, B) The data at APD₃₀ and APD₈₀, respectively. The box plots exhibit the impact of increasing the stimulation frequency from 55 to 75 bpm on these parameters. The two groups, WT vs. I79N^+/−, were compared using unpaired Student’s t tests with n = 5 biological and n = 2 technical replicates per condition. A p value <0.05 was considered statistically significant with the following notation: *p < 0.05, **p < 0.01, and ***p < 0.001.