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. 2021 Dec 17;9:787581. doi: 10.3389/fcell.2021.787581

FIGURE 4.

FIGURE 4

The influence of stimulation frequency on action potential duration (APD) and Ca2+ transient duration in WT (black) and I79N+/− (blue) TNNT2 hiPSC-CMs. (A, B) The analysis of these data at APD30 and APD80, respectively. The box plots exhibit the impact of increasing the stimulation frequency from 55 to 75 bpm on the APD30 and APD80, respectively. The box extends from the first to the third quartile; the line within the box is the median, and the downward and upward whiskers are the minimum and maximum data points, respectively. (C, D) The analysis of these data at CaTD30 and CaTD80, respectively. The box plots exhibit the impact of increasing the stimulation frequency from 55 to 75 bpm on the CaTD30 and CaTD80. The box extends from the first to the third quartile; the line within the box is the median, and the downward and upward whiskers are the minimum and maximum data points, respectively. The data from the two groups, WT vs. I79N+/−, were compared statistically using one-way ANOVA with Tukey test for multiple comparison correction with n = 5 biological and n = 2 technical replicates. Annotations are N.S for not significant, *p < 0.05, **p < 0.01, and ***p < 0.001.