Table 1.

Correlation between serum circMED27 and clinicopathological characteristics in 150 HCCs

Variable	circMED27		p value
	Low (n = 75)	High (n = 75)
Age (years)
≤50	43	49	0.402
>50	32	26
Sex
Female	23	31	0.234
Male	52	44
HBs Ag
Negative	4	6	0.745
Positive	71	69
HCV Ab
Negative	68	70	0.765
Positive	7	5
Liver cirrhosis
Yes	47	41	0.407
No	28	34
Serum AFP, ng/mL
≤20	52	34	0.005
>20	23	41
Serum ALT, U/L
≤75	34	37	0.744
>75	41	38
Tumor size (diameter, cm)
≤5	47	30	0.009
>5	28	45
Encapsulation invasion
Absent	45	39	0.411
Present	30	36
Vascular invasion
No	32	24	0.237
Yes	43	51
Tumor number
Single	31	27	0.615
Multiple	44	48
TNM stages
I/II	42	27	0.021
III/IV	33	48

HBs Ag, hepatitis B surface antigen; HCV Ab, hepatitis C virus antibody; AFP, alpha-fetoprotein; ALT, alanine transaminase.