Table 2.
Univariate and multivariate analyses of factors associated with overall survival
| Factors | OS |
|||
|---|---|---|---|---|
| Multivariate | ||||
| Univariate, p | HR | 95% CI | p value | |
| Sex (female versus male) | 0.243 | – | – | NA |
| Age (years) (≤50 versus >50) | 0.762 | – | – | NA |
| HBs Ag (positive versus negative) | 0.309 | – | – | NA |
| HCV Ab (positive versus negative) | 0.173 | – | – | NA |
| Liver cirrhosis (yes versus no) | 0.253 | – | – | NA |
| Serum AFP, ng/mL (≤20 versus >20) | 0.075 | – | – | NA |
| Serum ALT, U/L (≤75 versus >75) | 0.413 | – | – | NA |
| Tumor size (diameter, cm) (>5 versus ≤ 5) | 0.007 | 1.021 | 0.932–1.766 | NS |
| Tumor number (multiple versus single) | 0.247 | – | – | NA |
| TNM (III/IV versus I/II) | 0.069 | – | – | NA |
| circMED27 expression (high versus low) | 0.002 | 2.312 | 1.433–2.876 | 0.017 |
OS, overall survival; NA, not adopted; AFP, alpha-fetoprotein; HBs Ag, hepatitis B surface antigen; 95% CI, 95% confidence interval; HR, hazard ratio; NS, not significantly. ∗Cox proportional hazards regression model.