Table 3.
Univariate and multivariate analyses of factors associated with cumulative recurrence
| Factors | Cumulative recurrence |
|||
|---|---|---|---|---|
| Univariate, p | HR | Multivariate |
||
| 95% CI | p value | |||
| Sex (female versus male) | 0.232 | – | – | NA |
| Age (years) (≤50 versus >50) | 0.477 | – | – | NA |
| HBs Ag (positive versus negative) | 0.129 | – | – | NA |
| HCV Ab (positive versus negative) | 0.307 | – | – | NA |
| Liver cirrhosis (yes versus no) | 0.429 | – | – | NA |
| Serum AFP, ng/mL (≤20 versus >20) | 0.672 | – | – | NA |
| Serum ALT, U/L (≤75 versus >75) | 0.351 | – | – | NA |
| Tumor size (diameter, cm) (>5 versus ≤ 5) | 0.003 | 1.347 | 0.917–2.044 | 0.013∗ |
| Tumor number (multiple versus single) | 0.422 | – | – | NA |
| TNM (III/IV versus I/II) | 0.071 | – | – | NA |
| circMED27 expression (high versus low) | 0.006 | 1.502 | 0.814–1.923 | 0.029∗ |
NA, not adopted; AFP, alpha-fetoprotein; HBs Ag, hepatitis B surface antigen; 95% CI, 95% confidence interval; HR, hazard ratio. ∗Cox proportional hazards regression model.