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. 2021 Dec 17;12:789864. doi: 10.3389/fpsyt.2021.789864

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Copyright © 2021 Chen, Shi, Liu, Dai, Liu, Zhang, Du, Zhu, Yu, Fang and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Correlation between alpha diversity, microbiota genera, and clinical parameters in all participants. Heatmaps showing association between alpha diversity, microbiota composition, and clinical characteristics (A). *p < 0.05 and **p < 0.01. Total CARS score is negatively correlated with Chao1 index (B), Shannon index (C), InvSimpson index (D) in all participants. Genus Bacteroides (E), genus Faecalibacterium (F), and genus Oscillospira (G) based on the OTU profile were associated with CARS total scores. *p < 0.05, **p < 0.01, and ***p < 0.001.