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. 2021 Dec 17;12:760385. doi: 10.3389/fmicb.2021.760385

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Copyright © 2021 Huang, Ai, Ji, Tu, Gao, Wu, Yan and Yu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Bacillus smithii XY1 protects the intestine epithelium. (A) Hematoxylin and eosin (H&E) staining of a longitudinal section of zebrafish larvae intestine, scale bars, 50 μm, and yellow arrows indicate the length of the villi. Blue arrows indicate obvious gaps because of the thinner mucosal layer. (B) The mRNA level of immune-related genes including IL-1β, NOD2, IL-6, and TNF-α in the 6 dpf larvae. Data are presented as mean ± SEM. ^*p < 0.05 and ^**p < 0.01, analyzed by two-tail test. Every character represents the significance of a treatment group compared to the control group. n = 6 from three independent experiments.