Z-score signatures across different pathoanatomical groups. The Biomarker concentrations presented as means and standard errors of Z scores with the reference group being patients with a normal CT scan following TBI. Panel a shows mixed lesion (n=1313) and isolated pathology groups (Skull fracture (n=86), EDH (n=47), Acute SDH (n=89), SAH (n=184), IPH (n=41), DAI (n=31)) in relation to biomarker expression with patients with normal CT (n=1069) as the reference group. Panel b shows the number of different intracranial lesion types reported on each CT image for patients with mixed lesions, in relation to biomarker expression.