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. 2021 Dec 17;12:799861. doi: 10.3389/fimmu.2021.799861

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Copyright © 2021 Hugonnet, Singh, Haas and von Gunten

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Members of the four families of sialyltransferases catalyze different glycosidic linkages. (A) The four families of sialyltransferases as categorized according to restricted glycosidic linkage and acceptor specificity. Indicated are the transfer of activated CMP-Neu5Ac onto Gal, GalNAc or Neu5Ac moieties of carbohydrate chains (-R), such as on glycoproteins or glycolipids. (B) Examples of glycosidic α2,3, α2,6, and α2–8 -linkages involving the hydroxyl group at carbon atom 2 of Neu5Ac sialic acid with galactose (left, middle) or another sialic acid (right). CMP, cytidine monophosphate; Neu5Ac, N-acetylneuraminic acid; Gal, galactose; GalNAc, N-acetylgalactosamine.