Table 1.
Characteristics of included studies.
| Sl. No |
Authors | Year | Country | Nature of Study | Kellgren Lawrence Grade | Sample size | Treatment/Control | Mean Age (SD) |
Male/Female |
MSC Type | MSC Source | Follow-up (months) | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Treatment Group | Control Group | Treatment Group | Control Group | |||||||||||
| 1 | A Vega | 2014 | Spain | RCT | II, III, IV | 30 | 15/15 | 56.6 ± 9.24 | 57.3 ± 9.09 | 06/09 | 05/10 | BM | Allo | 12 |
| 2 | CT Vangness Jr | 2014 | USA | RCT | NR | 55 | 36/19 | 44.6 ± 9.82 | 47.8 ± 8 | 25/11 | 13/06 | BM | Allo | 24 |
| 3 | D Garay Mendoza | 2017 | Mexico | RCT | NR | 61 | 30/31 | 55.57 ± 12.02 | 59.32 ± 10.85 | 07/23 | 09/22 | BM | Auto | 6 |
| 4 | D Kuah | 2018 | Australia | RCT | I, II, III | 20 | 16/4 | 50.8 ± 7.29 | 55.0 ± 10.42 | 11/05 | 01/03 | AD | Allo | 12 |
| 5 | J Freitag | 2019 | Australia | RCT | II, III | 30 | 20/10 | 54.6 ± 6.3 | 51.5 ± 6.1 | 11/09 | 01/09 | AD | Auto | 12 |
| 6 | JM Lamo-Espinosa | 2016 | Spain | RCT | II, III, IV | 30 | 20/10 | 65.9 | 60.3 | 12/08 | 07/03 | BM | Auto | 12 |
| 7 | KL Wong | 2013 | Singapore | RCT | NR | 56 | 28/28 | 53 | 49 | 15/13 | 14/14 | BM | Auto | 24 |
| 8 | M Emadedin | 2018 | Iran | RCT | II, III, IV | 43 | 19/24 | 51.7 ± 9.2 | 54.7 ± 5.3 | 12/07 | 15/09 | BM | Auto | 6 |
| 9 | PK Gupta | 2016 | India | RCT | II, III | 60 | 40/20 | 58.10 ± 8.23 | 54.90 ± 8.27 | 12∖28 | 4∖16 | BM | Allo | 12 |
| 10 | S Wakitani | 2002 | Japan | I, II | 24 | 12/12 | NR | NR | NR | NR | BM | Auto | 16 | |
| 11 | TDX Tran | 2019 | Taiwan | RCT | II, III | 33 | 15/18 | 58.2 ± 5.70 | 59.0 ± 6.04 | 03/12 | 05/13 | AD | Auto | 24 |
| 12 | WS Lee | 2019 | South Korea | RCT | II, III, IV | 24 | 12/12 | 62.2 ± 6.5 | 63.2 ± 4.2 | 03/09 | 03/09 | AD | Auto | 6 |
| 13 | YG Koh | 2012 | South Korea | RCT | IV | 50 | 25/25 | 54.2 ± 9.3 | 54.4 ± 11.3 | 08/17 | 08/17 | AD | Auto | 16 |
| 14 | YG Koh | 2014 | South Korea | RCT | I, II, III | 44 | 23/21 | 52.3 ± 4.9 | 54.2 ± 2.9 | 06/17 | 05/16 | AD | Auto | 24 |
AD – Adipose derived; Allo – Allogenic; Auto – Autologous; BM – Bone Marrow derived; MSC – Mesenchymal Stem Cell; NR – Not Reported; RCT – Randomized Controlled Trial; SD – Standard Deviation; USA – United States of America.