Table 2.
Stem cell transplantation protocol of the included studies.
|
Study |
MSC Type | MSC Source | MSC Preparation |
MSC count (107 cells) | Treatment group Intervention | Control group Intervention | Outcome measures |
|---|---|---|---|---|---|---|---|
| A Vega | BM | Allo | CE-BMMSC | 4 | sIA Injection of MSC | sIA Injection of 60 mg HA | VAS, WOMAC |
| CT Vangness Jr | BM | Allo | CE-BMMSC | 5/15 | sIA Injection of MSC + 20 mg HA | sIA Injection of 20 mg HA | VAS, Lysholm Score |
| D Garay Mendoza | BM | Auto | BMC | 2 | 600 μg/day G-CSF for 3 consecutive days before the procedure + sIA Injection of MSC | Oral acetaminophen 500 mg every 8 h for 6 months |
VAS, WOMAC |
| D Kuah | AD | Allo | CE-ADMSC | 0.39–0.67 | sIA Injection of MSC | Placebo sIA Injection of cell culture media and cryopreservative | VAS, WOMAC, MRI assessment |
| J Freitag | AD | Auto | CE-ADMSC | 10/20 | sIA Injection of MSC ± 2nd injection at 6 months | Conservative management | VAS, WOMAC, KOOS, MRI assessment |
| JM Lamo-Espinosa | BM | Auto | CE-BMMSC | 1/10 | sIA Injection of MSC + 60 mg HA | sIA Injection of 60 mg HA | VAS, WOMAC, MRI assessment |
| KL Wong | BM | Auto | CE-BMMSC | 1.46 | HTO + Microfracture + sIA Injection of MSC + 20 mg HA | HTO + Microfracture + sIA Injection of 20 mg HA |
Tegner Score, Lysholm Score |
| M Emadedin | BM | Auto | CE-BMMSC | 4.1 | sIA Injection of MSC | Placebo sIA Injection of Normal Saline | VAS, WOMAC |
| PK Gupta | BM | Allo | CE-BMMSC | 2.5/5/7.5/15 | sIA Injection of MSC + 20 mg HA | Placebo sIA Injection of 20 mg HA | VAS, WOMAC, MRI assessment |
| S Wakitani | BM | Auto | CE-BMMSC | 1 | HTO + Microfracture + sIA Injection of MSC | HTO + Microfracture + Placebo injection | MRI assessment, HSS Knee rating scale |
| TDX Tran | AD | Auto | SVF | 10 | Arthroscopic micro fracture + sIA Injection of MSC | Arthroscopic micro fracture | WOMAC, MRI assessment |
| WS Lee | AD | Auto | CE-ADMSC | 10 | sIA Injection of MSC | Placebo injection with Normal Saline | WOMAC, MRI assessment |
| YG Koh | AD | Auto | SVF | 0.189 | Arthroscopic debridement + sIA Injection of MSC + PRP | Arthroscopic debridement + PRP | VAS, Tegner Score, Lysholm Score |
| YG Koh | AD | Auto | CE-ADMSC | 0.411 | HTO + sIA Injection of MSC + PRP | HTO + PRP | VAS, Lysholm Score |
AD – Adipose derived; Allo – Allogenic; Auto – Autologous; BM – Bone Marrow derived; BMC – Bone Marrow Concentrate; CE-ADMSC – Culture Expanded Adipose Derived MSC; CE-BMMSC – Culture Expanded Bone Marrow MSC; HA – Hyaluronic Acid;; HSS – Hospital for Special Surgeries; HTO – High Tibial Osteotomy; IA – Intra-articular; IKDC – International Knee Documentation Committee, KOOS – Knee Osteoarthritis Outcome Score; PRP – Platelet Rich Plasma; MRI – Magnetic Resonance Imaging; MSC – Mesenchymal Stem Cells; sIA – Single Intra-articular; SVF – Stromal Vascular Fraction; VAS – Visual Analog Score; WOMAC – Western Ontario Mc-Master Universities Osteoarthritis Index.