Table 1.

Summary of the impact of enzymatic GAG degradation and decorin and/or biglycan mouse knockout (K/O) on tendon quasi-static and viscoelastic material properties during fiber direction tension

Publication	Tissue	Treatment	Impact on quasi-static mechanics	Impact on viscoelastic mechanics
Lujan et al., 2007 [70]	Human MCL	Chondroitinase B	-- Peak stress, linear modulus	-- Hysteresis
Fessel and Snedeker, 2009 [25]	Rat tail tendon fascicles	Chondroitinase ABC	N/A	-- Storage modulus, loss modulus
Lujan et al., 2009 [71]	Human MCL	Chondroitinase ABC	N/A	-- Stress relaxation, dynamic modulus, phase shift, peak stress
Rigozzi et al., 2009 [72]	Murine Achilles tendon	Chondroitinase ABC	-- Ultimate stress, linear modulus, failure stress	N/A
Svensson et al., 2011 [26]	Human patellar tendon	Chondroitinase ABC	-- Linear modulus, peak stress, peak strain	-- Hysteresis
Legerlotz et al., 2013 [73]	Bovine extensor tendon fascicles	Chondroitinase ABC	-- Failure stress, failure strain, linear modulus	↑ Stress relaxation (after 300 s)
Robinson et al., 2004 [74]	Murine tendon tail fascicles	Decorin K/O	-- Peak stress, linear modulus	↓ Strain rate sensitivity
Zhang et al., 2006 [75]	Murine FDL tendon	Decorin K/O	-- Peak stress, linear modulus	N/A
Dourte et al., 2012 [76]	Murine patellar tendon	Decorin K/O	-- Toe modulus, linear modulus	-- Phase shift
Connizzo et al., 2013 [77]	Murine SST	Decorin K/O	-- Linear modulus	-- Stress relaxation
		Biglycan K/O	-- Linear modulus	-- Stress relaxation
Dourte et al., 2013 [78]	Murine patellar tendon	Biglycan K/O	-- Toe modulus, linear modulus	-- Stress relaxation
			↓ Failure stress	↑ Dynamic modulus
Robinson et al., 2017 [79]	Murine patellar tendon	Decorin and biglycan K/O	-- Linear modulus	↑ Stress relaxation, phase shift

(--) Indicates that there were no significant differences in the listed properties between control and treatment groups, (↑) indicates that the listed properties were significantly increased in the treatment group compared to the control group, and (↓) indicates that the listed properties were significantly decreased in the treatment group compared to the control group.