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. 2022 Jan 1;107(1):35–43. doi: 10.3324/haematol.2021.278755

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Figure 1. — Mechanism of action of selected novel agents for the treatment of marginal zone lymphoma. Bold type indicates approved agents, normal type indicates agents under investigation. IgH: immunoglobulin heavy chain; CD: cluster of differentiation; Syk: spleen tyrosine kinase; Btk: Bruton tyrosine kinase; PLCγ2: phospholipase Cγ2; PKCb: protein kinase Cb; PI3K: phosphatidylinositol-3-kinase; Akt: protein kinase B; bax: B-cell lymphoma-2 associated X protein; Bcl2: B-cell lymphoma protein-2; CAR: chimeric antigen receptor; PD-1, programmed cell death-1. Adapted from Cheah et al. J Clin Oncol 2016.