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Germline and somatic CBL mutations in patients with juvenile myelomonocytic leukemia. Each dot represents one mutation found at the specified codon. The resulting change in amino acid is coded by colors. The stars represent six patients found to have deletions. 4H: four helix bundle; EF: EF-hand like domain; SH2: Src homology 2 domain; L: linker domain; RF: ring finger domain; Pro-rich: proline-rich domain; UBA/LZ: ubiquitin-associated/leucine zipper domain.
