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Transcription factors cleaved by caspases
| Factor | Cleavage site | Cleavage caspase(s) | Consequence of cleavage | Reference or source |
|---|---|---|---|---|
| STAT1 | MELD | 3 | Reduced transcription | 41 |
| NFκB | Unknown | 3 | Reduced transcription | 58 |
| SP1 | Unknown | 1 | Unknown | 54 |
| GATA-1 | Unknown | 3, 7, 8, 9, 10 | Arrest of erythropoiesis | 16 |
| AP-2α | DRHD | 6, 3, 1a | Loss of DNA-binding activity | This paper |
AP-2α is cleaved by caspase 6 with the highest efficiency, by caspase 3 with less efficiency, and by caspase 1 with the least efficiency.
