TABLE 2.

Caspase 6 substrates

Protein	Cleavage site	Consequence of cleavage	Reference or source
Cytokeratin 18	VEVD	Keratin disruption	11
Lamin A	VEID	Nuclear lamin disassembly	56
NuMA	Unknown	Changed nuclear shape	28
MDM2	DVPD	Inhibits trans-activation	13
FAK	VSWD	Loss of paxillin binding activity	70
IκB	DRHD	NF-κB inhibition	3
Topoisomerase I	PEDD/EEED	Unknown	62
β-Catenin	Unknown	Disrupts actin	68
TGEV	VVPD	Unknown	21
AP-2α	DRHD	Loss of DNA-binding activity	This paper