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. 2021 Dec 14;143(51):21594–21603. doi: 10.1021/jacs.1c09573

Scheme 4. Hydrogenation Pathways for Class 2 Enamides.

Scheme 4

The enantioselective outcome for (E)-2a is dependent on the H2 pressure and the temperature. Low pressure and high temperature favor the isomerization toward (Z)-2a, enabling an enantioconvergent hydrogenation.