TABLE 1.
Demographic and clinical comparisons between AChEI groups—Full cohort. Bolded P‐values are significant at P<.05
| AChEI Group (N = 272)—MRI analysis | AChEI+ (121) | AChEI– (151) | P‐value |
|---|---|---|---|
| Baseline age, years mean (SD) | 73.0 (7.1) | 73.5 (8.2) | 0.612 |
| Sex, male % | 66.9 | 57.0 | 0.093 |
| Education, years mean (SD) | 16.0 (2.9) | 16.1 (2.8) | 0.747 |
| APOE ε4 alleles, % 0/1/2 | 40/45/16 | 58/34/7 | 0.005 |
| Baseline CDR‐SB, mean (SD) | 1.67 (0.88) | 1.39 (0.88) | 0.009 |
| Change in CDR‐SB [95% CI] | 2.66 [2.05, 3.27] | –0.06 [–0.61, 0.49] | <0.001 |
| Baseline MMSE, mean (SD) | 27.2 (1.73) | 27.8 (1.72) | 0.008 |
| Change in MMSE [95% CI] | –3.33 [–4.17, –2.48] | –0.20 [–0.97, 0.56] | <0.001 |
| Baseline Everyday Cognition Total Patient Score, mean (SD) | 1.61 (0.57) | 1.44 (0.39) | 0.025 |
| Baseline Everyday Cognition Total Informant Score, mean (SD) | 2.42 (0.83) | 1.65 (0.70) | <0.001 |
| Amyloid positive at baseline, positive % | 75.9 | 48.0 | <0.001 |
| Baseline bilateral hippocampal volume, mean mm3 (SD) | 6237.9 (1163.7) | 6915.0 (1071.9) | <0.001 |
| AChEI group (N = 192)—FDG analysis | AChEI+ (82) | AChEI– (110) | P‐value |
| Age, years mean (SD) | 73.1 (7.0) | 73.5 (8.1) | 0.700 |
| Sex, male % | 69.5 | 57.3 | 0.080 |
| Education, years mean (SD) | 16.1 (2.7) | 16.3 (2.5) | 0.600 |
| APOE ε4 alleles, % 0/1/2 | 37/48/16 | 56/36/8 | 0.025 |
| Baseline CDR‐SB, mean (SD) | 1.69 (0.90) | 1.43 (0.83) | 0.041 |
| Change in CDR‐SB [95% CI] | 1.97 [1.31, 2.63] | 0.33 [–0.31, 0.97] | <0.001 |
| Baseline MMSE, mean (SD) | 27.4 (1.8) | 28.0 (1.6) | 0.011 |
| Change in MMSE [95% CI] | –2.78 [–3.74, –1.81] | –0.88 [–1.80, 0.04] | 0.005 |
| Baseline Everyday Cognition Total Patient Score, mean (SD) | 1.61 (0.61) | 1.49 (0.42) | 0.181 |
| Baseline Everyday Cognition Total Informant Score, mean (SD) | 2.28 (0.79) | 1.65 (0.70) | <0.001 |
| Amyloid positive, positive % | 80.7 | 51.3 | <0.001 |
| Baseline PCC SUVR, mean (SD) | 1.53 (0.13) | 1.58 (0.15) | 0.011 |
Abbreviations: AChEI, acetylcholinesterase inhibitor; APOE, apolipoprotein E; CDR‐SB, Clinical Dementia Rating–Sum of Boxes; CI, confidence interval; FDG, fluorodeoxyglucose; MMSE, Mini‐Mental State Examination; MRI, magnetic resonance imaging; PCC, posterior cingulate cortex; SD, standard deviation; SUVR, standardized uptake value ratio.