TABLE 2.
Demographic and clinical comparisons between AChEI groups–Biomarker validated cohort. Bolded P‐values are significant at P<.05
| AChEI Group (N = 181)—MRI analysis | AChEI+ (83) | AChEI– (98) | P‐value |
|---|---|---|---|
| Baseline age, years mean (SD) | 72.6 (7.1) | 72.8 (8.5) | 0.859 |
| Sex, male % | 67.5 | 57.1 | 0.102 |
| Education, years mean (SD) | 16.0 (2.9) | 16.4 (2.4) | 0.272 |
| APOE ε4 alleles, % 0/1/2 | 41/45/15 | 58/36/6 | 0.036 |
| Baseline CDR‐SB, mean (SD) | 1.63 (0.85) | 1.38 (0.88) | 0.062 |
| Change in CDR‐SB [95% CI] | 2.58 [1.84, 3.33] | –0.39 [–1.09, 0.32] | <0.001 |
| Baseline MMSE, mean (SD) | 27.2 (1.8) | 27.9 (1.7) | 0.013 |
| Change in MMSE [95% CI] | –3.06 [–3.25, –1.86] | –0.70 [–1.84, 0.44] | 0.005 |
| Baseline Everyday Cognition Total Patient Score, mean (SD) | 1.62 (0.59) | 1.44 (0.40) | 0.046 |
| Baseline Everyday Cognition Total Informant Score, mean (SD) | 2.28 (0.78) | 1.62 (0.67) | <0.001 |
| Amyloid positive at baseline, positive % | 75.9 | 48.0 | <0.001 |
| Baseline Bilateral Hippocampal Volume, mean mm3 (SD) | 6384.9 (1132.0) | 7013.9 (1063.1) | <0.001 |
| AChEI Group (N = 137)—FDG Analysis | AChEI+ (57) | AChEI– (80) | P‐value |
| Age, years mean (SD) | 73.0 (6.8) | 73.1 (8.3) | 0.967 |
| Sex, male % | 71.9 | 53.8 | 0.023 |
| Education, years mean (SD) | 16.1 (2.6) | 16.5 (2.3) | 0.369 |
| APOE ε4 alleles, % 0/1/2 | 39/47/14 | 55/38/8 | 0.133 |
| Baseline CDR‐SB, mean (SD) | 1.67 (0.91) | 1.46 (0.88) | 0.176 |
| Change in CDR‐SB [95% CI] | 1.89 [1.34, 2.64] | 0.71 [–0.02, 1.44] | 0.028 |
| Baseline MMSE, mean (SD) | 27.4 (1.8) | 28.0 (1.6) | 0.034 |
| Change in MMSE [95% CI] | –3.15 [–4.51, –1.79] | –1.91 [–3.23, –0.58] | 0.197 |
| Baseline Everyday Cognition Total Patient Score, mean (SD) | 1.62 (0.64) | 1.48 (0.43) | 0.191 |
| Baseline Everyday Cognition Total Informant Score, mean (SD) | 2.20 (0.76) | 1.63 (0.67) | <0.001 |
| Amyloid positive, positive % | 80.7 | 51.3 | <0.001 |
| Baseline PCC SUVR, mean (SD) | 1.54 (0.13) | 1.57 (0.13) | 0.109 |
Abbreviations: AChEI, acetylcholinesterase inhibitor; APOE, apolipoprotein E; CDR‐SB, Clinical Dementia Rating–Sum of Boxes; CI, confidence interval; FDG, fluorodeoxyglucose; MMSE, Mini‐Mental State Examination; MRI, magnetic resonance imaging; PCC, posterior cingulate cortex; SD, standard deviation; SUVR, standardized uptake value ratio.