TABLE 3.

Association of BMI trajectories with cognition

	Model 1	Model 2
Entire sample	F(1,235) = 4.29, P = .040*	F(1,183) = 0.912, P = .341
Maternal AD	F(1,154) = 12.483, P = .001*	F(1,120) = 4.503, P = .036*
Paternal AD	F(1,70) = 1.047, P = .310	F(1,47) = .990, P = .325
Interactions a	r = .179 β = .704, P = .006*	r = .206, β = .817, P = .005*

Notes: Model 1 covariates: age, sex, education. Model 2 covariates: age, sex, education, APOE ε4, physical activity, diastolic blood pressure, systolic blood pressure, total cholesterol, diabetes status, creatinine.

^* P < .05.

^a Interactions between BMI and maternal/paternal family history on cognitive function.

Abbreviations: AD, Alzheimer's disease; APOE, apolipoprotein E; BMI, body mass index.