TABLE 2.
General linear model for single nucleotide polymorphisms on mini-mental score examination*.
| Gene | Additive model |
Dominant model |
Recessive model |
Interaction with APOE |
|||||||||
| Group | β | SE | p | β | SE | p | β | SE | p | Chi-square | p | effects | |
| CD2AP | GG compares to CC (1/3) | 9.180 | 3.8140 | 0.016 | 8.968 | 3.8115 | 0.019 | –1.025 | 0.8284 | 0.216 | 8.065 | 0.026 | Non-E4 |
| rs9349407 | CG compares to CC(2/3) | 8.437 | 3.8528 | 0.029 | |||||||||
| CD33 | CC compares to AA (1/3) | 1.810 | 2.0389 | 0.375 | 2.191 | 2.0287 | 0.280 | 0.875 | 0.7900 | 0.268 | 3.016 | 0.389 | – |
| rs 3865444 | CA compares to AA(2/3) | 2.992 | 2.0962 | 0.153 | |||||||||
| MS4AE4 | GG compares to TT (1/3) | 0.824 | 1.1392 | 0.470 | 1.054 | 1.0311 | 0.307 | 0.097 | 0.7921 | 0.903 | 3.252 | 0.354 | – |
| s670139 | GT compares to TT (2/3) | 1.221 | 1.0883 | 0.262 | |||||||||
| BIN1 | AA compares to GG (1/3) | –0.399 | 1.2194 | 0.744 | –0.043 | 1.1009 | 0.969 | 0.272 | 0.7868 | 0.729 | 2.559 | 0.465 | – |
| rs744373 | AG compares to GG(2/3) | 0.055 | 1.1708 | 0.963 | |||||||||
| PICALM | CC compares to TT (1/3) | –1.379 | 1.1078 | 0.213 | –1.294 | 1.0134 | 0.202 | 0.485 | 0.7764 | 0.532 | 2.523 | 0.471 | – |
| rs3851179 | CT compares to TT (2/3) | –1.222 | 1.0822 | 0.259 | |||||||||
| CLU | CC compares to TT (1/3) | –0.803 | 1.8222 | 0.660 | –0.310 | 1.8107 | 0.864 | 1.373 | 0.7766 | 0.077 | 3.730 | 0.292 | – |
| rs11136000 | TC compares to TT (2/3) | 0.650 | 1.8792 | 0.729 | |||||||||
| ABCA7 | TT compares to GG (1/3) | –0.371 | 1.1807 | 0.753 | 0.108 | 1.1082 | 0.922 | 0.808 | 0.7645 | 0.291 | 6.46 | 0.091 | – |
| rs3764650 | TG compares to GG(2/3) | 0.570 | 1.1754 | 0.628 | |||||||||
| MS4A6A | GG compares to TT (1/3) | –0.270 | 1.1356 | 0.806 | 0.461 | 1.0307 | 0.655 | 1.025 | 0.7877 | 0.193 | 5.518 | 0.138 | – |
| rs610932 | TG compares to TT (2/3) | 0.986 | 1.0831 | 0.362 | |||||||||
| FTMT | AA compares to GG (1/3) | –4.819 | 6.6353 | 0.468 | –4.801 | 6.6335 | 0.469 | 0.206 | 1.0325 | 0.842 | 1.974 | 0.160 | – |
| rs6887649 | AG compares to GG(2/3) | –4.708 | 6.6912 | 0.482 | |||||||||
| SPTLC1 | AA compares to GG (1/3) | 1.647 | 3.3356 | 0.622 | 1.465 | 3.3362 | 0.661 | –1.030 | 0.9562 | 0.28 | 7.282 | 0.053 | – |
| rs7849530 | AG compares to GG(2/3) | 0.661 | 3.4251 | 0.847 | |||||||||
| Intergenic SNP | AA compares to CC (1/3) | –1.747 | 2.1482 | 0.416 | –1.742 | 2.1286 | 0.670 | 0.161 | 0.7768 | 0.836 | 5.89 | 0.117 | – |
| rs4866650 | AC compares to CC(2/3) | –1.723 | 2.1886 | 0.428 | |||||||||
| P73 | GG compares to AA (1/3) | 0.436 | 1.1243 | 0.698 | 0.456 | 0.7792 | 0.559 | –0.201 | 1.0410 | 0.847 | 2.549 | 0.467 | – |
| rs3765728 | GA compares to AA(2/3) | 0.463 | 0.8381 | 0.581 | |||||||||
| FGF1 | GG compares to AA (1/3) | –0.625 | 1.2399 | 0.671 | –0.263 | 1.1872 | 0.825 | 0.576 | 0.7573 | 0.447 | 4.296 | 0.231 | – |
| rs34011 | GA compares to AA(2/3) | 0.064 | 1.2681 | 0.960 | |||||||||
| CR1 | AA compares to GG (1/3) | –5.326 | 6.6206 | 0.421 | 5.231 | 6.6324 | 0.430 | –2.032 | 1.6498 | 0.218 | 4.020 | 0.259 | – |
| rs6656401 | GA compares to GG(2/3) | –1.826 | 1.6971 | 0.282 | |||||||||
| EXOC3L2 | TT compares to CC (1/3) | 0.138 | 1.1541 | 0.905 | 0.329 | 1.0693 | 0.758 | 0.239 | 0.7718 | 0.757 | 7.673 | 0.045 | Non-E4 |
| rs597668 | TC compares to CC(2/3) | 0.499 | 1.1362 | 0.661 | |||||||||
*Adjusted for education, disease duration and age. SE, standard error.