TABLE 6.
Risk allele per structural covariance network of 15 tested single nucleotide polymorphisms (SNP) and ApoE4.
| Network | SNP | Risk allele | Unstandardized B (95%CI) | Standardized β | P-value |
| Basal ganglia | FGF1 (rs34011) | A-carrier | –0.261(–0.026∼–0.497) | –0.142 | 0.03 |
| Anterior Hippocampus | ApoE4 | E4 carrier | –0.344 (–0.619∼–0.069) | –0.164 | 0.014 |
| posterior Hippocampus | MS4A6A (rs610932) | T carrier | 0.292(0.024∼0.559) | 0.154 | 0.033 |
| Right Thalamus | MS4A6A (rs610932) | T carrier | 0.417 (0.121∼0.712) | 0.199 | 0.006 |
| Left Thalamus | BIN1 (rs744373) | TT | –0.294(–0.557∼–0.031) | –0.145 | 0.028 |
| Precentral Gyrus | APOE4 | E4 | 0.421 (0.173–0.669) | 0.217 | 0.001 |
| Supplementary Motor Cortex | APOE4 | E4 carrier | 0.302(0.074∼0.53) | 0.169 | 0.01 |
| CLU (rs11136000) | CC | 0.258(0.032∼0.484) | 0.143 | 0.025 | |
| CR1 (rs6656401) | A carrier | –0.482(—-0.954∼–0.011) | –0.130 | 0.045 | |
| Inferior Cerebellum | BIN1 (rs744373) | TT | –0.335(–0.607∼–0.062) | –0.161 | 0.016 |
| Medial Cerebellum | PICALM (rs3851179) | GG | –0.266 (–0.521∼–0.011) | –0.135 | 0.041 |
| Default Mode Network | CLU (rs11136000) | CC | –0.313(–0.566∼–0.06) | –0.157 | 0.016 |
| BIN1 (rs744373) | TT | 0.320(0.063∼0.576) | 0.161 | 0.015 | |
| Dorsal Attention Network | CR1 (rs6656401) | A-carrier | –0.640(–1.184∼–0.096) | 0.103 | 0.021 |
| FGF1 (rs34011) | A-carrier | 0.274(0.025∼0.255) | 0.137 | 0.031 | |
| MS4A6A (rs610932) | T carrier | 0.364(0.076∼0.652) | 0.175 | 0.014 |
The Multivariate linear model was used. Independent variables using ApoE4, rs9349407, rs3865444, rs670139, rs744373, rs3851179, rs11136000, rs3764650, rs610932, rs6887649, rs7849530, rs4866650, rs3765728, rs34011, rs6656401, rs597668, adjusted for age and gender; dependent variable is the network integrity score.