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. Author manuscript; available in PMC: 2021 Dec 31.
Published in final edited form as: Nat Struct Mol Biol. 2021 Nov 10;28(11):936–944. doi: 10.1038/s41594-021-00679-2

Extended Data Fig. 3. Comparison of the inactive β1-AR receptor with the activated β1-AR in complex with Gi.

Extended Data Fig. 3

(a-c) Side (left), extracellular (top right) and cytoplasmic (bottom right) views of the inactive β1-AR (grey)(PDB code 4GPO) compared to the activated β1-AR in complex with Gi. (d) Structural comparison of the Gi α5-helix binding region to show the major conformational changes of β1-AR. (e) The ionic lock between Arg139 and Glu285 is broken in the active state. (f) Tyr343 packs against Leu132 and Ile135 in the active state. (g) Cryo-EM density map of the Gi α5-helix binding region (contoured at 1.2 σ level).