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Numerical parameters in the PK-PD model to estimate extraction ratios of CPT-11 and SN-38 from the experimental data.
| Name | Description | Value | |
|---|---|---|---|
| w/o bypass channel | w/ bypass channel | ||
| Vd (μl) | Distribution volume | 70.19 | 85.01 |
| Q (μl/h) | Flow rate in the liver part | 89.60 | 26.45 |
| X0 (ng/μl) | Initial concentration of CPT-11 | 9.35 | 9.35 |
| fm | Fraction metabolized of CPT-11 by CES2 | 1 | 1 |
| Cell density ratio of A549 cells | 0.256 | 0.332 | |
