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Numerical parameters in the PK–PD model to estimate cell density ratios.
| Name | Description | Value | ||
|---|---|---|---|---|
| w/o inhibitors | w/ RTV | w/ SV | ||
| Vd (μl) | Distribution volume | 85.01 | 85.01 | 85.01 |
| Q (μl/h) | Flow rate in the liver part | 26.45 | 26.45 | 26.45 |
| X0 (ng/μl) | Initial concentration of CPT-11 | 9.35 | 9.35 | 9.35 |
| fm | Fraction metabolized of CPT-11 by CES2 | 1 | 1 | 1 |
| Ep | Extraction ratio of CPT-11 | 0.004 | 0.004 | 0.002 |
| Em | Extraction ratio of SN-38 | 0.084 | 0.084 | 0.084 |
