FIG. 8.

Microfiltration with horizontal arrangement. Bypass-channel design (a) allowed for one-bead-to-one-trap⁷⁹ and (b) single-cell capture.²⁸ Reproduced with permission from Tan and Takeuchi, Proc. Natl. Acad. Sci. U.S.A. 104, 1146–1151 (2007). Copyright 2007 National Academy of Sciences. Reproduced with permission from Kobel et al., Lab Chip 10, 857–863 (2010). Copyright 2010 Royal Society of Chemistry. (c) Cell-pairing also could be achieved by the bypass-channel. Reproduced with permission from Frimat et al., Lab Chip 11, 231–237 (2011). Copyright 2011 Royal Society of Chemistry. (d) Bypass-channel was able to generate static droplet arrays with gradient concentration. Reproduced with permission from Sun et al., Lab Chip 11, 3949–3952 (2011). Copyright 2011 Royal Society of Chemistry. (e) Crossflow microfiltration was able to control number of cells per trap by setting resistance of main channel and trap. Reproduced with permission from Chung et al., Lab. Chip 11, 3949–3952 (2011). Copyright 2011 American Chemical Society. (f) Mixture of 15 μm, 6 μm, and 3 μm particles was sorted by traps in different sizes. Reproduced with permission from Kim et al., Lab Chip 14, 2480–2490 (2014). Copyright 2014 Royal Society of Chemistry.