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. Author manuscript; available in PMC: 2021 Dec 31.
Published in final edited form as: Ann Surg Oncol. 2021 Jul 29;28(13):8556–8564. doi: 10.1245/s10434-021-10382-7

FIG. 1.

FIG. 1

Schematic of the oncolytic adenovirus. The replication of virus was controlled by the Cox2 promoter which was inserted upstream of the adenovirus E1 region as a tissue-specific promoter. Also, an expression cassette containing the adenovirus death protein (ADP) and the interferon alpha (IFN) transgene was inserted into place within the E3 region. For one of the control viruses, the luciferase transgene was used in place of IFN. Finally, the virus has the 5/3 chimeric fiber to enhance infectivity in cancer cells