Comparison 1. Modafinil versus placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Fatigue	1		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
1.1 Concentration problems	1	55	Mean Difference (IV, Fixed, 95% CI)	‐1.06 [‐3.18, 1.06]
1.2 Reduced motivation	1	55	Mean Difference (IV, Fixed, 95% CI)	‐0.48 [‐2.93, 1.97]
1.3 Reduced activity	1	55	Mean Difference (IV, Fixed, 95% CI)	‐1.01 [‐5.64, 3.62]
1.4 Fatigue severity	1	55	Mean Difference (IV, Fixed, 95% CI)	‐0.22 [‐0.79, 0.35]
2 Objective cognitive functioning	1		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
2.1 Verbal memory	1	53	Mean Difference (IV, Fixed, 95% CI)	0.26 [‐0.05, 0.57]
2.2 Working memory	1	53	Mean Difference (IV, Fixed, 95% CI)	0.07 [‐0.04, 0.18]
2.3 Attentional functioning	1	53	Mean Difference (IV, Fixed, 95% CI)	‐0.03 [‐0.05, ‐0.01]
2.4 Information processing	1	53	Mean Difference (IV, Fixed, 95% CI)	0.17 [‐1.19, 1.53]
2.5 Executive functioning	1	53	Mean Difference (IV, Fixed, 95% CI)	0.14 [‐9.33, 9.61]
2.6 Psychomotor speed	1	53	Mean Difference (IV, Fixed, 95% CI)	0.1 [‐0.26, 0.46]
3 Subjective cognitive functioning	1	55	Mean Difference (IV, Fixed, 95% CI)	1.62 [‐0.74, 3.98]
4 Depression	1	55	Mean Difference (IV, Fixed, 95% CI)	0.19 [‐1.33, 1.71]
5 Health‐related quality of life	1		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
5.1 Physical	1	55	Mean Difference (IV, Fixed, 95% CI)	1.34 [‐20.11, 22.79]
5.2 Mental	1	55	Mean Difference (IV, Fixed, 95% CI)	‐1.40 [‐4.84, 2.04]
6 Adverse events	1	55	Risk Ratio (M‐H, Fixed, 95% CI)	2.79 [0.59, 13.16]